DHSO rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES16949-50, ES16949-100

Citations, Manuals and MSDS Available upon request.

Background: Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD (+) cofactor.[supplied by OMIM, Jul 2010],

Source: Rabbit

Applications: WB; IP

Dilution: WB 1: 500-2000 IP 1:200

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human DHSO

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 6652

Human SWISS Prot NO: Q00796

Subcellular Location: Mitochondrion membrane; Peripheral membrane protein. Cell projection, cilium, flagellum. Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.

Research Use Only